Alopecia areata continues to be a challenging condition to treat for many patients. Recently, there have been some significant developments with potentially dramatic impact in helping patients with the most severe cases of alopecia areata. Both involve oral medications that affect the immune system and therefore have potential side effects associated with them. Currently, there are clinical trials underway to see whether or not topical treatments can be as effective with less potential side effects. We hope to see positive results in the near future.